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Wednesday’s news reports: February 25, 2009 — Part 3
Our third report today covers such topics as: A positive biopsy risk nomogram for men in New Zealand A review of current trends and priorities in surgical technique for radical prostatectomy A review...
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Your Wednesday news report: April 1, 2009
So let’s be completely clear … none of the items reported below are April Fool’s Day spoofs! Oxidative damage to DNA and risk for prostate cancer Accuracy of the Kattan nomograms whenb applied to...
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What our genes aren’t telling us … yet!
An important paper has just been published by a highly respected team of specialists doing research into the role of genetic variations in assessment of risk for prostate cancer. In this paper,...
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More genetic variants associated with prostate cancer
Two new papers published on line in Nature Genetics have added a total of nine more genetic variants to the number of variants associated with an increased risk for prostate cancer. Al Olama et al....
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Is free, circulating DNA a useful marker for prostate cancer?
Elevated levels of free, circulating DNA (fcDNA) have previously been been found in the serum of prostate cancer patients compared with the levels in the serum of patients with benign prostate...
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Chromosome catastrophe theory: an introduction to “chromothripsis”
According to a new paper in the journal Cell, researchers at the Sanger Institute at Cambridge, in England, believe they have discovered a completely new mechanism for the initial development of about...
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DNA methylation and the aggressiveness of prostate cancer
According to a media release from the Mayo Clinic earlier today, “Alterations to the ‘on-off’ switches of genes occur early in the development of prostate cancer and could be used as biomarkers to...
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A compound genetic/genomic and microenvironmental risk classification for...
As we become more knowledgeable about the underlying genetic and other factors that affect the risk for, and the risk for progression of, apparently localized prostate cancer, we also become more able...
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cfDNA from blood samples as a way to measure prostate cancer risk
According to a new article in the journal Clinical Chemistry, an international research team believes they have found a completely new way to test for risk of prostate cancer by measuring...
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Just how helpful is personalized genomic analysis anyway?
Regular readers of the medical science literature will be very conscious of the emphasis on genomic analysis of tumor specimens as a way to try to “personalize” treatment of cancers of many types —...
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The accurate assessment of risk profiles among high-risk prostate cancer...
A key question in management of prostate cancer is the risk that a particular patient has disease — at the time of diagnosis — that will progress over time to become metastatic. The ability to answer...
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Prevalence of DNA-repair germline mutations in men with metastatic prostate...
A new study in this week’s New England Journal of Medicine reports that DNA-repair germline mutations were found in nearly 12 percent of patients who had metastatic prostate cancer. DNA-repair germline...
View ArticleINO-5150 in early treatment of biochemically recurrent prostate cancer
In 2015, Inovio Pharmaceuticals started a Phase I trial of INO-5150 — a new type of immunotherapy using a DNA vaccine for prostate cancer which targets both prostate-specific antigen (PSA) and...
View ArticleLiquid biopsies, ctDNA, and the diagnosis and management of cancers
The American Society of Clinical Oncology (ASCO) and the College of Pathologists (CAP) have just issued a joint review of available information on clinical use of “liquid biopsies” to assess...
View ArticlePrediction of potentially lethal forms of prostate cancer
An international, multi-institutional group of researchers appears to have been able to validate a new way to predict risk for aggressive forms of localized prostate cancer that have a high probability...
View ArticleUnderstanding “cell-free DNA analysis” in cancer diagnosis and management
We have probably all heard terms like “liquid biopsy” and “genetic screening” and “cell-free” DNA analysis over the past few years. These are all terms related to the use of genetic and genomic...
View ArticleThe development of a “10-minute cancer test”: the Methylscape
By now, many readers have probably seen news reports coming out of Australia about the “possible medical breakthrough” of a rapid, highly accurate test that can be used to detect cancer anywhere in the...
View ArticleGermline genetic testing for men with prostate cancer
In this week’s Journal of Clinical Oncology, there is a full-text article in the “Comments and Controversies” section entitled “Germline testing for men with prostate cancer: navigating an expanding...
View ArticleDuctal adenocarcimoma of the prostate is “rare” but aggressive
Pure ductal adenocarcinoma of the prostate (dPC) is thought to be found in just 0.4 to 0.8 percent of men who get diagnosed with prostate cancer each year. However, it can also be found mixed in...
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